ERr 731 Pharmaceutical & NDI Home ERr 731 is an extensively researched, natural approach for hot flash relief. Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Scientists tested the rhapontic rhubarb extract in a placebo . The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio . Any product worth its salt will include the standardized rhapontic extract ERr 731, so make sure to check the ingredients list . The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. What are the side effects of Rhapontic rhubarb? Women who received placebo during the RCT and started taking ERr 731 in OS I reported a significant decrease in menopausal symptoms. Estroven's original formula uses only one active ingredient, 4 mg of ERr 731, a standardized extract from the root of Rhapontic Rhubarb. Long-term use can All three species are known by the common English name Chinese rhubarb. Distributed only by HRS to the World ERr 731 is an extensively researched, natural approach for hot flash relief. Results: Women in the ERr 731 group in the RCT experienced a further decrease in their symptoms during OS I. A preparation containing the Rheum rhaponticum extract ERr731 was registered as medicinal product in 1993 (Phytoestrol N, Chemisch-Pharmazeutische Fabrik Gppingen, Carl Mller, Apotheker, GmbH and Co KG, Gppingen, Germany), which was dedicated to alleviate menopausal complaints as an alternative for the hormonal replacement therapy (HRT). Altern Ther Health Med. In a clinical trial of 109 women approaching menopause, a rhapontic rhubarb supplement (ERr 731) reduced improved the quality of life and reduced symptoms such as the frequency and severity of hot flashes. . The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Rhubarb contains chemicals that might help heal cold sores and reduce swelling. ERr 731 has a fair amount of evidence to back its claim as a treatment for menopause symptoms. The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. German doctors have been using Estrovera to help their menopausal patients for 20 years. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Research has shown that rhapontic rhubarb can be an effective remedy for some of the symptoms of menopause, although the mechanism isn't 100% clear. 20 ICONIC BENEFITS OF RHUBARB 23 related questions found Does Siberian rhubarb help menopause? The Journal of Steroid Biochemistry and Molecular Biology Volume 128, Issues 1-2, January 2012, Pages 62-68 Long-term effects of the rhapontic rhubarb extract ERr 731 on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats Annekathrin MartinaKeiler1 AnjaPapke1 GeorgKretzschmar Oliver Zierau GnterVollmer Add to Mendeley 2008;14(6):32-8. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Rhubarb also contains fiber, which might help reduce cholesterol levels and affect stomach conditions. Results: After 6 months of treatment with ERr 731 in 252 women, there was a significant decrease of the MRS total score from 14.5 points at baseline to 6.5 points (P<.0001). It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731 that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies. Objective To demonstrate the ef cacy and tolerability of ERr 731 in menopausal women in everyday practice. Since the beginning of the 1990s, ERr 731 , an extract isolated from the roots of the Siberian rhubarb ( Rheum rhaponticum ), has been used regularly for the treatment of women suffering from oligomenorrhoea or amenorrhea (trade names Phyto-Strol , Mller-Gppingen and femi-loges , Loges). There is a report of kidney failure in someone who took a product containing rhubarb. Note: in botany, the species names "officinale" or "officinalis . Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. The reduction of the MRS score was more pronounced in women with a score of > or =18 points at baseline. Is Rhapontic rhubarb root extract ERr 731 Safe . The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Botanical Name: Rheum officinale, R. palmatum and R. tangutucum. 15, NO. This plant is a wild relative of the rhubarb plant used in cooking. Garden rhubarb (Rheum rhabarbarum), the familiar red-stalked rhubarb used in cooking in Europe and North America, is a different species and may not have the same medicinal properties. in a confirmatory rct involving 119 perimenopausal women, compared with perimenopausal women receiving placebo, those receiving err 731 experienced a median 83% decrease in daily hot flashes over the course of 12 weeks. compared to placebo, perimenopausal women who received err 731 (the extract found in estrovera) experienced a decrease in our results demonstrated two key features of err in the uterus of ovariectomized rats: (1) none of the tested doses of the extract if given alone stimulated uterotrophy (table 2) or marker gene expression associated with proliferative events (data not shown); (2) treatment of ovariectomized rats with combinations of low dose estradiol and err The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. ERr 731 can help women dealing with: Hot flashes Irritability Mood swings Sleep problems Exhaustion Vaginal dryness Joint and muscle discomfort In addition, it delivers results fairly quickly. A. . Because it may be associated with fewer side effects than conventional therapy, . Essentially, during menopause levels of estrogen decrease in the body, creating symptoms like hot flashes and night sweats. The trial, which was conducted at University Hospital, Frankfurt, Germany, showed that women who consumed one tablet containing 4 mg of the extract Rheum rhaponticum, or ERr 731, every day for 12 weeks had a significant reduction in the number and severity of hot flashes, compared with women who took placebo. The key ingredient in Estrovera is a phyto-estrogen from the Siberian rhubarb plant known as ERr 731, which has been shown to: Reduce the number and severity of hot flashes and night sweats about as effectively as low-dose estrogen. Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of . Importantly, this supplement didn't alter gynecological factors such as uterus health or bleeding [ 21 ]. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Its active ingredient is rhapontic rhubarb extract. Estroven claims that this ingredient activates estrogen receptors and reduces menopausal symptoms. 1 25 aglycones, rhapontigenin and desoxyrhapontigenin.6 Neither rhapontic rhubarb nor the special extract ERr 731 contains any of the anthraquinones such as emodin or rhein that are found in other rhubarb species.7 Thus, this extract has no laxative effect. It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731 that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies. An older study from 2008 found that. Researchers found 12 weeks of treatment with a pill containing extract of Rheum rhaponticum, the vegetable more commonly known as rhubarb, significantly reduced the frequency and severity of. The active ingredient in Estrovera is a standardized extract of rhapontic rhubarb ( Rheum rhaponticum ). Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 . Background The special extract ERr 731 from the roots of rha-pontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:bene t ratio in daily use. Ef cacy of ERr 731 in Perimenopause ALTERNATIVE THERAPIES, jan/feb 2009, VOL. . Richardson A, et al. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. 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